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Host cell DNAs or residual DNAs (rDNAs) are trace/low quantity of DNA originating from the organisms used in the production process of biopharmaceutical products, which may be introduced into the final products. The rDNAs may be able to transmit viral infections, cause a potential risk for oncogenesis or adverse reactions, etc. To assure the safety and potency, rDNAs in final biopharmaceutical products must be carefully monitored and quantitated, following the requirements established by World Health Organization (WHO), the European Pharmacopeia, the US Food and Drug Administration (FDA), and

The disulfide bond plays an important role in maintaining the spatial three-dimensional structure of peptides and proteins and the biological activity determined thereby, and is also related to the stability and renaturation of proteins. Analysis of disulfide bonds and free sulfhydryl groups on proteins helps to analyze the high-level structure of proteins to reveal the biological functions of proteins. Disulfide bond analysis can analyze the structural characteristics of protein to improve its degradation stability and prolong its efficacy. The analysis of disulfide bonds in proteins is an i

Therapeutic proteins products have been proven effective against various diseases. Complex post-translational modifications (PTMs) are required by most therapeutic proteins. Common PTMs include glycosylation, oxidation, deamidation, proteolysis, and so forth. These PTMS not only affect efficient secretion, drug efficacy and stability of therapeutic proteins, but also may influence safety, immunogenicity, serum clearance, pharmacokinetics, etc.

Phosphorylation is a common post-translational modification (PTM) of proteins in eukaryotes, which functions in various cell activities, including glycolysis, protein-protein interaction, protein degradation, enzyme inhibition, homeostasis, and so forth. Protein phosphorylation is a reversible process of attachment of a phosphoryl group to proteins catalyzed by enzymes, principally on serine, threonine or tyrosine residues. Approximately 30% of proteins subject to phosphorylation in eukaryotic cells are tightly associated with protein activity by changing conformation of phosphorylated protei

Creative Proteomics provides reliable, rapid and cost-effective qualitative and quantitative N-glycan analysis and N-glycan structural analysis services.

Creative Proteomics is specialized in offering melatonin analysis service powered by UPLC-MS/MS, contributing to elucidating the functions, biological synthesis, metabolism, and networks of melatonin.

Creative Proteomics offers analysis of salicylic acid and its derivatives based on state-of-the-art LC-MS/MS platforms in MRM mode, as well as tailored statistical analyses and bioinformatics analyses to satisfy your project needs.

Our amino acids analysis services adopt the technology platform (HPLC, automatic amino acid analyzer, LC-MS/MS) to perform qualitative and quantitative analysis of a variety of free amino acids in your samples.

Phosphatidylserine is a phospholipid and is a component of the cell membrane and plays a key role in cell cycle signaling. Creative Proteomics provides comprehensive phosphatidylserine targeted lipidomics services base on LC/MS for biomedical research institutions, biotechnology, and pharmaceutical companies.

Glycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. Creative Proteomics provides reliable glycerophospholipids targeted lipidomics services for our customers.

With an integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective sterol lipids lipidomics services.

Creative Proteomics provides comprehensive maresins targeted lipidomics services from lipid extraction, lipid detection and data analysis for biomedical research institutions, biotechnology and pharmaceutical companies.

Creative Proteomics provides IL-12 detection services and selects proprietary solutions based on your samples and requirements to assist your experiment.

Creative Proteomics provides TGF-β detection services and selects proprietary solutions based on your samples and requirements to assist your experiment.

Creative Proteomics provides TGF-α detection services and selects proprietary solutions based on your samples and requirements to assist your experiment.

Creative Proteomics provides chemokines CX3C subfamily detection service and selects optimal solutions based on your samples and requirements to help your experiment.

bile acid quantification

Glycosaminoglycans are large complex carbohydrate molecules that interact with a wide range of proteins involved in physiological and pathological processes. Glycosaminoglycans are sometimes known as mucopolysaccharides because of their viscous, lubricating properties, as found in mucous secretions. These molecules are present on all animal cell surfaces in the extracellular matrix, and some are known to bind and regulate a number of distinct proteins, including chemokines, cytokines, growth factors, morphogens, enzymes and adhesion molecules.

It is now well established that deficiencies of the major dietary sources of methyl donors, methionine and choline, lead to the formation of liver cancer in rodents. Although not so widely studied as the liver tumors, extrahepatic tumor formation has also been increased in carcinogen-treated animals fed diets low in the methyl donors methionine, choline, and folic acid. Several

When DNA is attacked by oxidative stress such as ROS, ultraviolet light, or genotoxic agents, guanine is easily oxidized into 8-hydroxydeoxyguanosine (8-OHdG). The existence of this oxidized guanine in genomic DNA can cause transversion mutation such as G-T or G-A binding, accumulation of which can lead to detrimental consequences.